Center Scientifique de Monaco esale e le setho ho tloha ka 1931.
Centre Scientifique de Monaco (CSM) ke setsi sa sechaba se ikemetseng sa monogasc se thehiloeng ka 1960 ke Prince Rainier III. Leha lipatlisiso tsa mahlale e bile moetlo Monaco ka nako e fetang lilemo tse lekholo ka mor'a leeto la Leoatle la Prince Albert Ist, litakatso tsa Khosana Rainier III ha a theha CSM e ne e le ho fana ka mokhoa oa ho etsa lipatlisiso le ts'ehetso ea eona ea mantlha ea Monaco. ketso ea mekhatlo ea 'muso le mekhatlo ea machaba ho sireletsa le ho baballa lintho tse phelang metsing. Ho tloha ka 1990, CSM e ntse e ithuta haholo ka tikoloho ea lebopo la leoatle mme haholoholo likorale tsa tropike le tse futhumetseng mabapi le phetoho ea maemo a leholimo lefatšeng ka bophara. Lithahasello tsa hae tsa lipatlisiso li kenyelletsa mekhoa ho tloha ho genomics ho ea ho ecology ka biochemistry le physiology.
Ka 2010, CSM e ile ea bula lihlooho tse ncha: moruo oa tikoloho le mokhatlo oa lichelete oa lipatlisiso tsa bongaka ka ho sebelisana le mekhatlo ea tlhokomelo ea bophelo ho Principality. Ka 2012, ntle le Lefapha la Biology ea Marine, ho ile ha thehoa mafapha a mabeli a macha a lipatlisiso: lefapha la Polar Biology, haholo-holo ho ithuta linonyana tsa polar tse sebelisoang e le matšoao a phello ea boemo ba leholimo tikolohong ea Subantarctic le Antarctic le lefapha la Medical Biology le kenyeletsang lihlopha tse 'nè tse sebetsang Biology ea mofets'e, li-biotherapies tse sebelisoang ho mafu a neuromuscular le gut microbiota. Ka 2016, Setsi sa Scientifique de Monaco se ile sa fetoha Setsi se sebelisanang sa Mokhatlo oa Lefatše oa Bophelo.
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